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How to use cyclosporine and tacrolimus correctly?

2018-04-19 15:37

Cyclosporine and tacrolimus are suitable for the prevention of allograft rejection of kidney, liver, heart, bone marrow and other organs or tissues. In recent years, they have been widely used in kidney disease.

If you are a patient with kidney disease who is about to change kidneys or plan to have a kidney transplant, you can learn about the precautions of these two drugs.

How to use cyclosporine and tacrolimus correctly?

1, Avoid eating time while taking both medications, either 1 hour before or 2 hours after meal.And the time between the two medication should be about 12 hours.

2. Regularly monitor the blood drug concentration before taking the drug. In summary, the blood concentration of cyclosporine can generally be maintained at 100 to 150 ng/ml, and the plasma concentration of tacrolimus can be maintained at 5 to 10 gn/ml. If the blood and urine concentrations of these two drugs do not reach the therapeutic concentration, the therapeutic effect will be less than expected or even ineffective; if the blood concentration exceeds the treatment concentration limit, it will increase the risk of drug-related adverse reactions.

Therefore, the doctor will adjust the dose of the drug according to the level of blood drug concentration so that the blood drug concentration is maintained as far as possible in a safe and effective range.

3, monitoring blood concentration must be taken before the morning medication, after taking the drug.

4. If the patient is stable with a brand of medication, it is not recommended to change the brand.

5, some drugs will affect the blood concentration of these two drugs.

Drugs that increase plasma concentrations include methylprednisolone, allopurinol, colchicine, danazol, nicardipine, and erythromycin.

Drugs that reduce plasma concentrations include rifapentine, octreotide, and orlistat. Be cautious about medication.

6, Beware of the side effects of these two drugs.

The side effects of cyclosporine include nephrotoxicity, hypertension, metabolic abnormalities, infection, thrombotic microangiopathy, gingival hyperplasia, and gastrointestinal reactions. The side effects of tacrolimus mainly include nephrotoxicity, hyperglycemia, infection, and thrombotic microangiopathy.

In order to reduce side effects, it is recommended to start with small doses and monitor serum drug concentration and renal function level until blood drug concentration is stable.

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