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Gout is caused by renal failure

2016-12-28 15:58
Gouty nephropathy damage to the kidney is a very slow process, the patient's renal function can be maintained for many years, so, for the relevant content of the disease we need to know more about. So, gout is caused by renal failure is how to look at the following experts to introduce the relevant content:
Experts pointed out that the disease often quiet, symptoms hidden, such as the continuous development of disease, appear edema, oliguria, proteinuria, nocturia, hypertension, anemia and renal damage that performance, finally the development of renal failure, and death due to azotemia and uremia. Look at the following specific.
Gout is a purine biosynthesis due to increased metabolism, produce too much uric acid or due to elevated uric acid excretion of uric acid in the blood caused by incorrect, urate crystal deposition caused by synovial bursa, cartilage and other tissues of recurrent inflammatory disease. It is a heterogeneous disease caused by the formation of a supersaturated state of sodium urate crystals (MSU) or uric acid in the extracellular fluid. The disease in synovial fluid and gout stone can be found in a double refraction single water sodium urate crystal for its characteristics. Its clinical features are: hyperuricemia and urate crystal deposition, due to the characteristic of acute arthritis, gout, interstitial nephritis, severe joint deformity and dysfunction, often accompanied by urinary calculi uric acid. The etiology is divided into two categories: primary and secondary.
Experts: uric acid is the final product of the catabolism of purine compounds in humans, when hyperuricemia, uric acid, which is deposited in the salt of the kidney lesions, that is, gouty nephropathy. The main damage parts of gouty nephropathy were renal tubules and renal interstitium. Uric acid deposition in the renal tubules and renal interstitium, resulting in renal tubular epithelial cells atrophy, degeneration, and damage to renal tubular function. Renal interstitial edema, inflammatory response, fibrosis can occur for a long time, the clinical interstitial nephritis. Uric acid on glomerular damage as renal tubule and renal interstitium, but also can cause inflammation of the glomerular capillaries and glomerular basement membrane, which can sometimes be found in glomerular sclerosis, that glomerular filtration function is compromised. Renal arteriolar sclerosis and glomerulosclerosis are two important causes of renal failure.
Gouty renal failure is caused by how? Because of gouty nephropathy is chronic progressive development in the early, can not have any clinical symptoms, even in the middle of renal failure, azotemia symptoms are not typical, just as waist soreness, fatigue, nocturia, urine protein or some. There will be edema, hypertension etc.. The signals from these kidney diseases are often difficult to detect. Therefore, suggestions have been investigated in patients with hyperuricemia, even if they do not have any clinical manifestations, should also be regularly to the hospital to check the body, such as urine routine, renal function, blood lipid, blood sugar and so on, in order to know whether the protein or hematuria, renal function is normal, blood glucose and blood lipids, we found that the issue of timely treatment, care of the kidney.
The article is an expert on the introduction of gouty renal failure, we should have a clear understanding of gouty renal failure, I hope the contents of the above can bring you help.
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