home >>

What are the clinical manifestations of chronic renal failur

2016-12-25 11:44
After the renal failure disease, we need to pay attention to it, do early detection and early treatment, the only way to a point away from the disease, early to get rid of this illness and distress, so more to understand the relevant symptoms of renal failure diseases is also very necessary, each one is willing to an early rehabilitation of patients. The clinical manifestations of chronic renal failure, we need to correctly understand, because of chronic renal failure severely affect everyone's health, will bring great risks to everyone, in order to get rid of harm caused by the disease and associated complications, we must pay attention to the clinical manifestations of chronic renal failure, and early detection, early treatment, this is the embodiment of your responsibility.

Clinical manifestations of chronic renal failure:
Phase 1: compensatory phase of renal function:
Renal function compensatory glomerular filtration rate reduced to 30-60 ml / min, while normal glomerular filtration rate of 120 ml per minute. The nephron reduction about 20%-25%. renal reserve capacity has been lost, but the excretion of metabolites, regulation of water electrolyte and acid-base balance ability is good, so no special clinical manifestations, serum muscle enzymes and blood urea nitrogen is usually normal or sometimes slightly increased.

Phase two: 
Azotemia reduced glomerular filtration rate to 25 ml / min, nephron reduction 50%-70%, concentration of renal dysfunction, appeared nocturia or polyuria, often have varying degrees of anemia, azotemia, serum creatinine and urinary nitrogen. Clinical weakness, anorexia, nausea and mild physical discomfort. This period, such as ignoring the protection of renal function or the body additional load, there will be severe vomiting, diarrhea, caused by insufficient blood volume, if the feeling or use of nephrotoxic drugs, can cause rapid decline in renal function and failure.

Three stage: renal failure period (pre uremia):
During renal failure, glomerular filtration rate was reduced to 10-15 ml per minute, renal unit was reduced by about 70%-90%, renal function was severely damaged, and metabolism, water electrolyte and acid-base balance could not be maintained. Can not maintain the body environment is stable, so that blood creatinine, urea nitrogen significantly increased, urinary concentration and dilution dysfunction, acidosis, retention of sodium and water, low calcium, high phosphorus, high potassium imbalance performance. Can have obvious anemia and intestinal symptoms, such as nausea, vomiting, decreased appetite. Also can have the neuropsychiatric symptoms, such as fatigue, inattention, depression etc..

Phase four: Uremia
Glomerular filtration rate decreased to 10 ml per minute -15 ml, renal unit is reduced by more than 90%, this is the late period of chronic renal failure, clinical symptoms of the renal failure more obvious manifestations of systemic multiple organ failure, such as gastrointestinal tract, nervous system, cardiovascular system, blood system, respiratory system, skin and metabolic system imbalance. The clinical manifestations of nausea and vomiting, irritability, increased blood pressure, palpitation, chest tightness, supine, dyspnea, severe anemia, severe convulsions, coma, often with hyperkalemia, hyponatremia, hypocalcemia and hyperphosphatemia. This period requires dialysis to sustain life. Often due to hyperkalemia, cerebral edema, pulmonary edema, heart failure and sudden death.
please leave a message if you have questions,experts will reply to you soon,and help you relieve the pain.
Join over 37,000 people who receive bi-weekly professional nephropathy guidance.