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Impact of chronic renal failure on patients

2016-12-25 09:56
Chronic renal failure will bring inconvenience to patients mainly have the following points:
1 increased urinary protein excretion in patients with chronic renal failure, resulting in edema and hypoproteinemia, and accelerated tubular glomerular damage.
2 of patients with tubulointerstitial inflammatory cell infiltration, which can release growth factors and inflammatory mediators, stimulate collagen deposition and increased mesangial matrix, leading to glomerulosclerosis and tubulointerstitial fibrosis.
3 renal tubular ammonia secretion increased, although this can reduce the incidence of acidosis in patients with chronic renal failure, but accelerated tubulointerstitial damage.
4 patients with renal failure rate per unit increase of residual renal glomerular filtration function, nephron loss compensation to the role of the body's metabolic waste excretion, but due to residual renal unit load, again accelerated glomerular damage, such as caused by glomerular hypertrophy.
Steps in the diagnosis of renal failure
1 urinary sodium quantity >30mmol/l. This is also an effective basis for diagnosis, filtration sodium excretion fraction (FENa) measurement, the law of the disease must have significance.
2, blood urea nitrogen and creatinine increased. Is also an important step in the diagnosis of renal failure, but nitrogen can not be alone as a diagnostic basis, due to renal function when the digestive tract bleeding patients usually urea nitrogen also increased. The blood of patients with renal failure increased creatinine, blood urea nitrogen and serum creatinine were less than or equal to 10 is the main purpose of diagnosis. In addition, urine / blood urea (< 15 usual in urine 200-600mmol/24h, urine / blood urea >20), also have the diagnostic value of urinary creatinine is less than or equal to 10.
3 pure water cleaning rate set, in normal circumstances, this approach will help early diagnosis, this is the need to understand. Pure water clearance rate = urine volume (1 hours) (1- urine osmotic pressure / blood pressure), its usual -30, the greater the back value, kidney function is super. Closer to 0, the more severe renal function. -25 ~ -30 of renal function and head transformation. -25 to -15 shows mild and moderate renal damage. -15 to 0 shows kidney function cool destroyed.
4 blood test, blood test is a necessary examination in the examination of the disease. We all know that red blood cells and hemoglobin fall, white blood cells increase, thrombocytopenia. Potassium, magnesium and phosphorus in blood increased, usual or slightly falls short of sodium, calcium fall short, carbon dioxide combining power also fall short.
5 urine examination, this type of test we can according to the following data to judge. Oliguria, urine is less than 17ml/h or <400ml/d, urine specific gravity short, <1.014 and fixed at about 1.010, the urine acidic urine protein binding + to + + +, microscopic examination of urine visible thick tube type heavy slag particles, a few red and white blood cells, these are very good interpretation of the renal failure.
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