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Positive urine test is kidney trouble?

2017-01-16 11:47

Different from other pathological types, what is the biggest characteristic of nephrotic syndrome? The typical symptom is that we call the "three high and one low", namely, proteinuria, edema, hyperlipidemia, hypoproteinemia, the incidence of it is more and more inclined to young people.

And we have to solve today's problems is suffering from nephrotic syndrome in the crowd, why there will be a lot of urinary protein leakage? Or, when it is discovered that the positive urine test, it should consider whether the kidney is out of the question?

19 year old Xiao Yong appeared high urine protein problem, to the hospital when his urine protein quantitative has reached 6.70g/24h, originally very thin a guy legs swollen particularly thick.

Relative to the small permanent swelling, mother is more worried about the positive urine test, because she heard that the nephrotic syndrome is difficult to cure, and the risk of recurrence is particularly high.

His mother's worries and doubts for the Department of Nephrology expert Dr. Shi Wei in the round time she spoke to the problem of positive urine test. The fundamental reason is that the damage to the glomerular filtration barrier, resulting in leakage of plasma proteins into the urine, more than the re absorption capacity of renal tubules, resulting in urine test was positive, which is the typical symptoms of nephrotic proteinuria.

In order to make you more clearly understand the formation of proteinuria, Shi Wei gave us an example.

Water and solute in the blood by glomerular filtration into the renal capsule to form primary urine, must pass through the capillary wall endothelial cells, basement membrane and epithelial cells, the three layer structure called the glomerular filtration membrane. The three layer filtration membrane has a certain pore, can only allow a certain molecular weight and the diameter of the material through the filtration membrane, thus constituting the aperture barrier, and the surface structure of three layers were coated with sialic acid protein, glomerular basement membrane inner and outer loose layer with heparan sulfate, these substances with negative charge in the human body environment in the exclusion of solute with negative charge through, so as to form the charge barrier filtration membrane. In addition, the glomerular mesangial membrane within the glomerular capillaries has a regulatory effect on glomerular filtration barrier, and thus plays an important role in glomerular filtration. Under normal circumstances, the vast majority of the blood. Proteins cannot pass through the glomerular filtration barrier, especially macromolecules and negatively charged albumin almost completely, and a small amount of small molecular proteins that are filtered through membranes can be reabsorbed in the tubules. Thus, although about 10 to 15kg of plasma proteins flow through the renal circulation. But the protein excreted from the urine is less than 150mg. In nephrotic syndrome, because of a variety of pathological factors, the barrier function of filtration membrane is damaged, such as pore size or negative charge is reduced, resulting in a large number of protein leakage, heavy absorption capacity and far more than the renal tubules, the emergence of massive proteinuria.

Nephrotic syndrome is difficult to cure, and the risk of recurrence is particularly high.

His mother's worries and doubts for the Department of Nephrology expert Dr. Shi Wei in the round time she spoke to the problem of positive urine test. The fundamental reason is that the damage to the glomerular filtration barrier, resulting in leakage of plasma proteins into the urine, more than the re absorption capacity of renal tubules, resulting in urine test was positive, which is the typical symptoms of nephrotic proteinuria.

Clear the reasons for the emergence of proteinuria in order to fundamentally treat. A few days after hospitalization, Xiao Yong edema disappeared. After half a month, examination results show that urinary protein quantitative down to 1.02g/24h.

 

 

 

 

 

 

 

 

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