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Concern about the causes of glomerulonephritis disease

2016-12-27 14:41
The disease causes glomerulonephritis is a complicated disease, suffering from the treatment of glomerulonephritis this disease can not be blind, blind to the consequences are unpredictable, blind treatment may cause unwanted consequences in sick time according to the disease etiology, symptomatic treatment measures. Together to pay attention to the causes of glomerulonephritis disease?
The disease often due to hemolytic streptococcus "nephritogenic strains" caused by infection, common upper respiratory infection (mostly tonsillitis), scarlet fever, skin infection (mostly impetigo) and streptococcal infection.
Can also be pathogenic bacterial infections, including bacteremia, viral and parasitic disease, Streptococcus pneumoniae, Staphylococcus and Staphylococcus aureus, Klebsiella pneumoniae, Salmonella typhi meningitis, etc..
According to years of research, this disease is an immune complex glomerulonephritis caused by infection of beta hemolytic streptococcus A group. According to: 1 nephritis before onset of Streptococcus precursor infection; this disease generally does not occur in the peak chain infection. 2 there is no evidence of direct invasion of kidney by streptococcus. 3 from streptococcal infection to nephritis occurred in an intermittent period, and in Streptococcus infection after the onset of 1 or 2 to 3 weeks, this period is equivalent to the time required for antibody formation. 4 antibodies and immune complexes against Streptococcus and its products were detected in blood. 5 decreased complement components in blood. 6 renal biopsy revealed deposition of IgG and complement in the glomerular basement membrane.
Vary with course of disease and severity of disease. The proliferation and swelling of diffuse glomerular capillary endothelial cells were observed under light microscope, and the degree of capillary lumen was obstructed. Mesangial cells also proliferate and swell, with neutrophils and neutrophils, monocytes infiltration, fibrin deposition, glomerular capillary blood flow disorders, causing ischemia, glomerular filtration rate decreased. Glomerular basement membrane was normal, but under electron microscope, there was a "Hump" high density sediment on the basement membrane. Immunofluorescence examination showed that C3 and IgG were deposited in the "Hump", and there were diffuse coarse particles deposition along the capillary wall and mesangial area. The main components were IgG and C3, IgA and IgM were rare. But rare G1q and C4 deposition. The change of serum complement and glomerular capillary loop was C3, properdin deposition, complement activation may show is the main way of alternative pathway.
We in the comprehensive reading. After experts have learned about kidney disease glomerulonephritis complicated causes of disease, the cause for the drug, in order to achieve the desired effect, hope to understand these complex diseases can help people to pay attention to disease prevention for glomerulonephritis, also suffered from the disease according to the causes of symptomatic response measures to prevent actively, such a process of active treatment.
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