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What are the common treatment options for IGA nephropathy?

2017-12-09 17:26

IgA nephropathy is the most common primary glomerular disease, it belongs to the mesangial proliferative glomerulonephritis, but has also become a pathological type alone, so now often say mesangial proliferative glomerulonephritis, actually refers to the pathological types in non IgA deposits.

IgA is part of the body's immune system. The so-called IgA nephropathy is the deposition of these IgA immune complexes in the mesangial area of the kidney, triggering the complement system attack, leading to kidney damage. Therefore, the key to the treatment of IgA nephrosis is to clean up these immune complexes as soon as possible.

The treatment of IgA nephropathy should be based on different clinical and pathological types of treatment. The principles of treatment include:

To remove the infection focus: in the use of antibiotics to control infection, we should strive to remove the infection, such as tonsillitis, rotten teeth, or perianal abscess.

Prevention and control allergen: if you are allergic to some substance, allergy will make the disease difficult to control and easy to recur, so try to avoid contacting allergens.

Control blood pressure: the purpose of controlling blood pressure is to help control the proteinuria, reduce the pressure of the capillary inside the glomerulus and protect the function of the kidney.

The hormone and immunosuppressant control of active immune inflammatory lesions: if renal biopsy are glomerular cellular crescents, mesangial proliferative lesions should be combined with other activities, whether the patient has proteinuria, presence of renal dysfunction, use of hormones, cyclophosphamide, Tripterygium wilfordii, or tacrolimus, mycophenolate new immunosuppressive treatment phenolic ester.

Delaying the progress of renal function: controlling the high risk factors of aggravating renal damage, such as correcting hyperuricemia, hyperlipidemia, improving anemia, high quality and low protein diet, and keeping renal function as stable as possible, and delaying the progress of renal function.


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