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Causes of glomerulonephritis

2016-12-27 11:40
What is the incidence of glomerulonephritis, it is estimated that many people know it, it should be how to prevent, how to treat, how should make the corresponding response. With the treatment of glomerulonephritis disease we can not blindly, according to the causes of the symptomatic treatment measures, but also the only way to a little earlier from disease glomerulonephritis, get rid of some suffering, health is most necessary, so to be able to calm the life to focus on the causes of glomerulonephritis is disease necessary.
The disease often due to hemolytic streptococcus "nephritogenic strains" caused by infection, common upper respiratory infection (mostly tonsillitis), scarlet fever, skin infection (mostly impetigo) and streptococcal infection.
1 bacterial infection also can cause disease, including bacteremia status, various viral and parasitic disease, Streptococcus pneumoniae, Staphylococcus and Staphylococcus aureus, Klebsiella pneumoniae, Salmonella typhi meningitis, etc..
According to years of research, this disease is an immune complex glomerulonephritis caused by infection of beta hemolytic streptococcus A group. According to the first 1: nephritis before the onset of the disease streptococcus infection; generally do not occur in the chain of infection peak, 2 there is no direct evidence of Streptococcus invading the kidney; 3 streptococcal infection nephritis to a break; but in 1 weeks or 2 ~ 3 weeks after streptococcal infection incidence, this a period equal to the time required for 4 antibody formation in patients with detectable antibodies to Streptococcus and its products, immune complex; complement component 5 in blood decreased; 6 renal biopsy revealed deposition of IgG and complement in the glomerular basement membrane.
2 vary with course of disease and severity of disease. The proliferation and swelling of diffuse glomerular capillary endothelial cells were observed under light microscope, and the degree of capillary lumen was obstructed. Mesangial cells also proliferate and swell, with neutrophils and neutrophils, monocytes infiltration, fibrin deposition, glomerular capillary blood flow disorders, causing ischemia, glomerular filtration rate decreased. Glomerular basement membrane was normal, but under electron microscope, there was a "Hump" high density sediment on the basement membrane. Immunofluorescence examination showed that C3 and IgG were deposited in the "Hump", and there were diffuse coarse particles deposition along the capillary wall and mesangial area. The main components were IgG and C3, IgA and IgM were rare. But rare G1q and C4 deposition. The change of serum complement and glomerular capillary loop was C3, properdin deposition, complement activation may show is the main way of alternative pathway.
After a comprehensive reading of the contents of this article introduced, we have also understood the reasons for the formation of glomerulonephritis, understanding the pathogenesis of nephropathy, understanding how should medication, how to treat the original disease. Know the causes of this disease is more complex.
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