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Do you know how allergic purpura nephritis is happening?

2017-06-06 10:23

Henoch-Schonlein purpura nephritis is clinically a type of human capillaries allergic disease because the disease can cause renal damage due to glomerular capillaries and interstitial blood vessels, external manifestations of edema, proteinuria, Hematuria and renal dysfunction. Occurrence of Henoch-Schonlein purpura nephritis patients are common in children and adolescents, adults are rare, occur in the cold season, male and female incidence was no significant difference.

The cause of purpuric nephritis is mainly associated with infection and allergic reactions, and its related factors are:

① infection: bacteria to β hemolytic streptococcus caused by the most common upper respiratory tract infection, in addition to Staphylococcus aureus, pneumococcus, Mycobacterium tuberculosis and rubella, chicken pox, measles and influenza viruses and intestinal parasites and other infections.

② food: the patient of fish, shrimp, crab, eggs, milk and other food allergy protein allergy.

③ drugs: the commonly used antibiotics (penicillin, streptomycin, chloramphenicol, erythromycin), a variety of sulfonamides, antipyretic analgesics (salicylic acid, aminopyrine, (Synthetic aldehydes, testosterone propionate, insulin), anti-tuberculosis (isoniazid), other drugs and chemical substances such as digitalis (other than), sedatives (phenobarbital, chloral hydrate, tranquil) , Quinidine, atropine, methadone, D860, iodide, gold, arsenic, bismuth, mercury and other allergic reactions.

④ other allergic factors: such as cold, trauma, insect bites, pollen, vaccination, tuberculin test, menopause and even mental and other factors.

All of the above factors have a sensitizing effect on some people, so that the body produces allergic reactions. The pathogenesis of allergens (food, drugs, bacteria, viruses, toxins, etc.) cause immune complex formation and deposition in the kidney, induced immune injury and vasculitis. In the majority of patients with serum IgA levels can be increased, and after the onset of glomerular and skin may have immunoglobulin and complement deposition.

Half of patients with purpura nephritis 1 to 3 weeks before the onset of upper respiratory tract infection history, and some have a clear history of allergies, there may be fever, limbs stretch side of the bleeding purpura, joint pain, gastrointestinal symptoms (abdominal pain, blood in the stool, hematemesis) Renal manifestations. Kidney disease occurs more than 2 to 4 days after the emergence of purpura, inpidual patients can be used as the first symptom in the skin, gastrointestinal, joint symptoms before. Most of the prognosis of the disease is good, there are self-limiting, there are repeated attacks or months or even years. The prognosis depends mainly on the severity of nephropathy. Recent studies have also found that the incidence of Henoch-Schonlein purpura nephritis and the genetic quality of patients there is a certain relationship.

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