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What are the causes of acute interstitial nephritis

2017-05-26 11:05

What are the causes of acute interstitial nephritis? Acute interstitial nephritis is essentially a syndrome characterized by a sharp decline in renal function, renal interstitial edema and inflammatory cell infiltration, no glomerular and vascular system damage. The disease can be caused by a variety of reasons, the most common cause of drug and infection and allergic pathogenic microorganisms. Systemic disease caused by less common, some of the reasons for the onset of unknown. Although the diagnosis based on clinical manifestations and laboratory tests can be made, but the diagnosis depends on renal pathological examination. Here we come to understand the etiology of acute interstitial nephritis.

Acute interstitial nephritis rapid onset to the renal interstitial inflammatory cell infiltration as the main lesion characteristics, renal tubular degeneration of patients with varying degrees of renal insufficiency with a group of diseases. Often manifested as unexplained. Sudden decline in renal function, changes in renal function was a brief decline in the weight of those who showed significant acute renal failure of oliguria.

Most patients before the onset of fever, rash, joint pain, peripheral blood eosinophils increased, especially in drug-induced acute interstitial nephritis was significant. As a result of interstitial edema caused by the expansion of renal cysts, patients often have low back pain and kidney area percussion pain, hypertension, edema and acute glomerulonephritis characteristics in acute interstitial nephritis rare.

Although acute interstitial nephritis has a variety of clinical manifestations, it must be emphasized that the absence of any one or all of the symptoms is not uncommon, therefore, for unexplained acute renal failure, must pay great attention to interstitial nephritis may Adversely affected by illness. Laboratory examination may have hematuria, and often for the naked eye hematuria, especially in the drug caused by common, even visible erythrocyte tube type, may have sterile pyuria and white blood cell tube type.

Most patients have mild to moderate proteinuria, but non-steroidal anti-inflammatory drugs are often caused by a large number of proteinuria, urinary sediment increased eosinophils. Renal tubular dysfunction is common, according to interstitial inflammation spread of the kidney unit segments, proximal tubule reabsorption function of the damage can be expressed as normal blood sugar, urine, amino acid and small protein proteinuria, can also have distal tubule function Damage, such as urinary acidification dysfunction, isotonic urine, potassium excretion and so on.

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