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What is the purpose of IgA nephropathy?

2017-03-26 14:29

Medication of IGA nephropathy 

☆ What are the main causes of IgA nephropathy?

IgA nephropathy is one of the most common chronic nephritis species in the Asian population. There is no evidence of the exact cause, but many evidence shows that IgA nephropathy and mucosal chronic infection, such as chronic tonsillitis, sinusitis, enteritis and so on. 

☆ What are the main clinical manifestations of IgA nephropathy?

IgA nephropathy, only a small number of patients was found that urine appeared red blood cells in the physical examination . Without any uncomfortable at the first time, if not physical examination he may not find the disease. Some patients will appear proteinuria, hematuria, but only a certain amount of proteinuria in the case, only the face and lower limb edema. Heavy cases, manifested as high blood pressure, elevated serum creatinine, found when it has entered the uremic stage. 


purpose of IgA nephropathy

☆ IgA kidney disease is often accompanied by other complications and why?

Can appear naked hematuria, often after the cold increase. Also prompted the disease with a great relationship with the infection.

A large number of patients with proteinuria will be edema, mild only edema of the face or eyelid, severe systemic edema, and even pleural effusion, ascites.

Creatinine increased, will be associated with nephrotic anemia, which is due to the reduction of erythropoietin produced by the kidneys.Other can occur in high blood pressure, because the water and sodium feel, renal secretion of renin levels increased.

The purpose of treatment is to reduce proteinuria, stabilize renal function, delay renal failure. But not the disappearance of hematuria for the purpose, which requires special emphasis.

☆ why IgA nephropathy must be diagnosed before treatment?Treatments are necessary?

Clinical can be pided into simple hematuria, proteinuria + hematuria, nephrotic syndrome, renal failure and other types and staging.

Not every need for treatment, simple hematuria can be observed. Protein urine is less than 1.0g / 24h can not use immunosuppressive agents, first with ACEI or ARB class of antihypertensive drugs, proteinuria may be serious use of immunosuppressive agents, and even a variety of drug treatment. Renal failure may require dialysis treatment.

☆ what are IgA kidney disease commonly used drugs?

Simple to be pided into immunosuppressive agents and non-immunosuppressive agents.

Immunological preparations include steroid hormones such as prednisone, methylprednisolone, prednisolone, cyclophosphamide, leflunomide, cyclosporine, mycophenolate mofetil,Non-immunosuppressive agents include ACE inhibitors, ARB-type antihypertensive drugs, antiplatelet agents, and proprietary Chinese medicines.

☆ Under what circumstances should the joint medication? What are the main joint programs?

At present, the amount of proteinuria is less than 1.0g / 24h, mainly non-immunosuppressive agents. Large amount of protein, the need to use immunosuppression. In most cases, immunosuppressive agents are required in combination with nonimmunotic inhibitors. The use of a regimen for the treatment of IgA nephropathy, which contains the impact of methylprednisolone, drops the dose of prednisone every other day.

☆What is the integrated treatment of chronic kidney disease?

The basic understanding is that once the occurrence of kidney disease is included in the whole process of management, at different stages of the disease to choose the most appropriate patient program intervention, rather than just a stage of treatment of the disease.

☆ kidney problems, to cut tonsils?

This issue is controversial and is currently inclined to cut. But more slowly infected more obvious, my personal opinion is recommended to remove.

☆ what circumstances to do dialysis?

When the blood creatinine level increased, more than 707umol / L, severe edema, heart failure, severe acidosis, hyperkalemia, obvious symptoms of uremia, such as nausea and vomiting can not eat one of the cases, you need dialysis.

☆ What is the case to do kidney transplantation?

Chronic renal failure, and B-ultrasound imaging prompted renal sclerosis, atrophy, the performance of end-stage renal failure, in which case conditions can be considered kidney transplantation.

☆ What are the prognosis of IgA nephropathy is not ideal? why?

Pathological manifestations of severe, there is anemia, creatinine increased, low calcium, high phosphorus, B super-echo enhancement and pulp boundaries do not ask patients with poor prognosis.

☆ IgA patients how to follow? What is the frequency?

According to the pathological situation and the severity of the disease, usually 2-4 weeks referral time, mild, such as simple hematuria can be 3-6 months to see an outpatient clinic.


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