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What are the factors leading to the onset of IgA nephropathy

2017-02-21 10:01

Progressive factors in IgA nephropathy include both controllability and uncontrollability. Uncontrolled factors are mainly genes, race, age and gender. The focus of this paper is to explore the predictability of control factors, to seek effective intervention measures, try to reverse or eliminate these factors, so as to achieve the purpose of delaying the progress of kidney disease. Clinical progress in the common control of the main factors are the following aspects.

1, renal ischemia. IgA nephropathy and other chronic kidney disease, any cause of effective circulation of blood shortage factors, such as dehydration, surgery, all kinds of stress, etc., will lead to kidney ischemia, so that the sick kidney is worse, increasing kidney damage. Although most of these factors are reversible, but the ischemia is long, the degree of heavy, it may become irreversible damage.

2, kidney poisoning. The most common cause of kidney poisoning is drugs, including direct toxic effects and allergy to drugs. Some drugs may not have much adverse effects on normal kidneys, but may cause more severe or even irreversible damage to patients with kidney disease.

3, infection. The effect of infection on IgA nephropathy is more pronounced than that of other chronic kidney diseases. Such as skin, mucous membranes, tonsils and other infections, may increase the damage to the kidneys, manifested as gross hematuria or urine abnormalities increased. Severe infection may also affect renal function.

4, pregnancy. On the impact of pregnancy on IgA nephropathy, each report is different. Most scholars believe that the impact of pregnancy on IgA nephropathy than minor lesions, membranous nephropathy and mild non-IgA mesangial proliferative glomerulonephritis greater impact. For patients with IgA nephropathy with normal blood pressure and renal function, pregnancy has no significant effect on the natural course of kidney disease. However, compared with peers without kidney disease, pregnancy may be more prone to pregnancy-induced hypertension syndrome, increased blood pressure, increased proteinuria, decreased renal function, the vast majority of these changes can be restored to pre-pregnancy levels of pregnancy, A few may become irreversible. However, for patients with hypertension, renal insufficiency and large amounts of proteinuria, pregnancy may aggravate the kidney damage of pregnant women themselves and may affect the development and survival of the fetus. These patients have a higher risk of pregnancy.

5, high blood pressure. Hypertension, family history of hypertension, hypertriglyceridemia, hyperuricemia, and obesity are factors that contribute to IgA nephropathy. Hypertension is IgA nephropathy progress to the most important risk factors for renal failure, especially in patients with proteinuria. If the urine protein> 1g / 24h, blood pressure> 130 / 80mmHg, indicates that kidney disease will progress. The blood pressure control in the 125 / 75mmHg or less, can reduce the risk of hypertension. Because of the large fluctuations in blood pressure, the mean arterial pressure during the observation period is an independent factor affecting the progression of IgA nephropathy compared with the blood pressure before the renal biopsy.

6, proteinuria. The prognosis of IgA nephropathy is related to the amount of urine protein, duration, and the composition of urinary protein. Urine protein is generally considered> 1g / 24h is the risk of IgA nephropathy. Some people think that tubular small molecule proteinuria, especially α1-microglobulin, and IgA nephropathy related to the poor prognosis. In addition, the increase of cytokine interleukin-6 (IL-6), monocyte chemoattractant factor-1 (MCP-1) and the decrease of epithelial growth factor (EGF) are also the risk factors of IgA nephropathy.

7, bad habits. Mental stress, reduced activity, high salt, high fat and high protein and high purine diet lead to high blood pressure, high blood lipids, high uric acid, glomerular high load and obesity. Obesity is not only affecting the progress of chronic kidney disease, but also with the occurrence and development of glomerulonephritis, overweight IgA nephropathy patients progress faster. Experimental studies have shown that obesity and caffeine consumption are associated with proteinuria and are associated with tubulointerstitial damage. Smoking also affects the occurrence and development of chronic kidney disease and has been found to have a significant increase in the risk of end-stage renal disease with increased smoking. Often and excessive drinking also increases the risk of end-stage renal disease.

8, cell proliferation. IgA nephropathy common cell proliferation mainly glomerular mesangial cell proliferation and wall epithelial cell proliferation (cell crescent formation), often appear different degrees of hematuria. Crescent volume and degree of heavy, often associated with renal insufficiency. These changes can accelerate the progression of kidney dis

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