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What is diabetic nephropathy?

2017-02-10 14:48

Diabetic nephropathy is one of the most important complications of diabetes mellitus, which is a serious disease of diabetes. The lesions may involve renal vessels, renal tubules and interstitium. Renal damage is common in diabetic glomerular sclerosis, vascular sclerosis, pyelonephritis, renal papillary necrosis and urinary protein, etc.. The diabetic glomerulosclerosis is the renal complications of diabetes is rare, clinically known as the diabetic nephropathy. Diabetic nephropathy is an important cause of death in diabetic patients. Some statistics, in middle-aged patients with diabetes, the incidence of diabetic nephropathy was 20%, the elderly patients up to 65%.

To supplement the diabetic nephropathy:

Generalized diabetic nephropathy include:

1, diabetes mellitus (diabetes mellitus) is characterized by (1) diabetic glomerular sclerosis, nodular; diffuse.

(2) diabetic renal tubular nephropathy.

2, diabetic renal arteriosclerosis (non diabetic patients who are unique).

3, kidney infection (non diabetics).

(1): acute and chronic pyelonephritis.

(2) necrotizing.

Manifestation and staging of diabetic nephropathy:

Glomerular filtration rate (GFR) was increased in 1 cases. If corrected hyperglycemia, GFR changes can be reversed. The pathological examination in glomerular fat outside, no other organic diseases.

(2) during the period of renal impairment no clinical manifestations: GFR normal or higher; pathological changes: mesangial matrix increased slightly wide, slight thickening of the glomerular basement; urinary albumin excretion rate (UAER) and <20ug/min (3) of early diabetic nephropathy: GFR normal; pathological changes: mesangial matrix and thickening of glomerular basement is slightly widened more obvious; urinary albumin excretion rate (UAER): 20ug/min~200ug/min (4): GFR reduced clinical diabetic nephropathy; pathological changes: glomerular sclerosis, tubular atrophy and interstitial fibrosis; proteinuria: >0.5g/d (5): GFR severely impaired renal failure stage; pathological changes: glomerular sclerosis, tubular atrophy, deserted. And renal interstitial fibrosis; proteinuria.


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