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Mesangial proliferative glomerulonephritis

2017-01-05 16:21

Mesangial proliferative glomerulonephritis (mesangial proliferative, glomerulonephritis, MsPGN) is a pathological diagnosis of diffuse mesangial cell proliferation and mesangial matrix increased in different degrees as the main pathological features. In 1970, Chnrg et al. First reported the disease in pediatric patients, and then in Morel-Mamger, et al., and Hayslett et al. In adults in the United States in the year of, in 1972. In 1977, MsPGN was officially classified as a pathological type of primary glomerular disease by the WHO (WHO).

According to the pathology of MsPGN can be divided into IgA nephropathy (mesangial area dominated by deposition of IgA) and non IgA nephropathy in two categories, the former has been made about the topic in the third chapter, here only intends to introduce non IgA mesangial proliferative glomerulonephritis (non IgA MsPGN).

Non IgA MsPGN is a common pathological type of primary glomerular disease in our country. In 1988, No.1 Hospital of Peking University made a clinical and pathological analysis. According to the report of renal biopsy in late 1980s in Beijing, Nanjing, Shanghai and China Guangzhou, non IgA MsPGN about adult primary glomerular disease renal biopsy were 24.7% ~ 30.3%, far higher than the statistics of American and European countries, such as Cohen in the estimation of renal biopsy cases in only about 5% ~ 10%, 2006 Ba two Malafronte reported this disease in primary glomerular disease renal biopsy cases accounted for only 3.8%. There has been a discussion on the causes of the differences, some people think that the race may be related to genetic background, 1989 and 1993 Hoy reported that Native American Indians MsPGN incidence rate is much higher than that in Caucasian, this provides some evidence. But the renal biopsy indications, pathological specimen level (such as light slice thickness and immunofluorescence reagent quality prison etc.) and disease diagnosis standard of different understanding, is another major factor causing this difference. According to the data of renal biopsy in China-Japan Friendship Hospital of the Ministry of health in the past 8 years, it was found that non IgA MsPGN accounted for only about 14.7% of the primary glomerular disease (unpublished).


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