A cruel fact: The prevalence of skin cancer in patients who have undergone kidney transplants has become higher than that of ordinary people. Common types of skin cancer after renal transplantation Keratoderma: It is generally considered to be precancerou...
A cruel fact: The prevalence of skin cancer in patients who have undergone kidney transplants has become higher than that of ordinary people.
Common types of skin cancer after renal transplantation
Keratoderma: It is generally considered to be precancerous lesion, mainly manifested as red, rough, prickly or burning sensation, which usually appears on the exposed skin: Bald head, face, upper limbs and back of the hand. If not treated, it can be transformed into squamous cell carcinoma.
Squamous Cell Carcinoma: The most common skin cancer after kidney transplantation is related to sun exposure. Mainly for the head and neck, back skin red, scaly bulge, the skin lesions are difficult to heal. The incidence of this disease in kidney transplant patients is approximately 65 times that of the general population.
Basal cell carcinoma: The second highest incidence of skin cancer after kidney transplantation is mainly a small pink bulge or macule on the skin, which can be repeatedly ruptured and bleeding to form hard skin. The incidence of this disease in renal transplant patients is approximately 10 times that of the general population.
Melanoma: The most aggressive skin cancer. The main manifestations are brown, red and black spots on the skin. The incidence of the disease in kidney transplant patients is about 3 to 4 times that of the general population.
Kaposi’s sarcoma: mainly manifested as red, pink, purple patch or rash. The incidence of kidney transplant patients is only 0,5%.
Skin cancer is the most common after organ transplantation. The longer the postoperative survival, the higher the incidence, and poses a greater threat to the lives of long-term survivors of kidney transplant recipients.
The present study considers that the long-term use of immunosuppressive agents in kidney transplant recipients reduces the body's immune system and causes the body to lose the ability to monitor and repair cancerous cells, leading to the occurrence of cancer.
There is a Langerhans cell in the skin that is involved in local immune surveillance in the epidermis and can defend against skin tumours.
Studies have shown that the density of Langerhans cells at the skin lesions of renal transplant recipients is significantly reduced, presumably because this leads to a lack of immune regulation and immunosurveillance, a decrease in the anti-tumor defensive ability, and an increase in the incidence of skin cancer.
Other studies have found that the incidence of HPV infection in the skin, mucous membranes, and skin cancers of kidney transplant recipients is significantly higher than that of the general population. It is also speculated that HPV infection is likely to occur due to immunosuppression and may activate HPV proliferation, leading to increased risk of skin tumors.
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