What harm does proteinuria have to the body? There are more and more patients suffering from kidney disease now, urinary protein is a significant symptom of kidney disease, the symptoms of the disease is complicated, and easily neurasthenic symptoms combi...
What harm does proteinuria have to the body? There are more and more patients suffering from kidney disease now, urinary protein is a significant symptom of kidney disease, the symptoms of the disease is complicated, and easily neurasthenic symptoms combined with the treatment effect is not good, there is no standard cure to the patient's harm is great, the urinary protein on the body what harm?
1.it caused aggravation of tubulointerstitial hypoxia: proteinuria reabsorption of a large number of protein to digest the extra energy, cause tubular cell hypoxia, so as to cause tubular cell damage.
2.Toxic effects on proximal tubule cells: Occurrence of proteinuria, the amount of protein in renal tubular epithelial cells into increased to lysosomal activity increased, indicating that protein induced lysosomal spill into tubular cell plasma, subsequent cell injury can stimulate inflammation and scar formation.
3. Biological changes in tubular cells: Many renal diseases in which proteinuria occurs are characterized by an overgrowth of cells that represent a non adaptive response leading to renal failure. More and more evidence shows that protein can directly regulate the function of tubule cells, change its growth characteristics and expression of cytokines and matrix proteins, which can lead to the release of PDGF, FN and MCP-1 from the basal ganglia.
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