Protein urine is one of the main clinical manifestations of patients with chronic nephritis, and often lingering and difficult release, not only affect the rehabilitation of the disease, but also because of a large number of loss of protein and endanger l...
Protein urine is one of the main clinical manifestations of patients with chronic nephritis, and often lingering and difficult release, not only affect the rehabilitation of the disease, but also because of a large number of loss of protein and endanger life. Therefore, the control of proteinuria is very important for preventing the formation of hypoproteinemia and the recurrence and deterioration of nephritis. At present, there are some methods to treat proteinuria of glomerulonephritis:
Adrenocortical hormone therapy: can be used for nephrotic syndrome, more use of prednisone, adult initial amount of 40-60 mg / day, for 4-6 weeks, then subtract 5 mg per week, until the withdrawal of the whole course of treatment for 3-6 months.
Intravenous immunoglobulin: this drug mechanism may lie in the immune complex immune globulin combined with glomerular, change the crystal state, thereby promoting the dissolution or closure of the macrophages and B cells of the Fc receptor, thus inhibiting the synthesis of B lymphocyte antibody.
Angiotensin converting enzyme inhibitors: in recent years, the use of such drugs in the treatment of non diabetic nephrotic syndrome, can reduce urine protein 30% ~ 50%, and the effective group of proteinuria renal function is also stable. No hemodynamic changes in the kidney.
Nonsteroidal anti-inflammatory drugs: these drugs can inhibit the production of prostaglandin PGE2, reduce the local inflammatory and permeability of the kidney, and have a positive effect on reducing urinary protein. But because of the decrease of PGE2, the distribution of intrarenal blood flow, the decrease of renal cortical blood flow, and the decline of glomerular filtration rate. Therefore, it is not recommended to use this kind of medicine to reduce urine protein. Moreover, the effect of this kind of medicine is very unstable, and it is repeated several weeks after stopping the drug.
Anti platelet aggregation drugs and anticoagulant therapy: these drugs may improve the function of blood coagulation in glomerular capillaries, and are used in nephrotic syndrome without definite results.
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