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Analysis of renal tubular proteinuria and glomerular protein

Analysis of renal tubular proteinuria and glomerular protein

Clinically for a variety of classification of proteinuria, according to the source of proteinuria can be pided into renal tubular proteinuria and glomerular proteinuria and so on. So, what is the meaning of glomerular proteinuria and renal tubular protein...


Clinically for a variety of classification of proteinuria, according to the source of proteinuria can be pided into renal tubular proteinuria and glomerular proteinuria and so on. So, what is the meaning of glomerular proteinuria and renal tubular proteinuria? How is it formed? What are the symptoms of these proteinuria?

What is glomerular proteinuria? 

Glomerular proteinuria refers to the glomerular filtration membrane permeability increased, so that a large number of protein filtered into the glomerular filtrate, far more than the renal tubular reabsorption capacity, resulting in proteinuria. This proteinuria clinically the most common, more common in primary or secondary glomerular disease, renal circulation disorders, hypoxia and so on. Urine protein can be from a small amount (200mg / 24h urine) to more than 10g daily, most> 2g / 24h urine, which is usually characterized by albumin, but when the glomerular filtration membrane damage, some molecular weight Large globulin, β-lipoprotein ratio will increase. Urine protein disc electrophoresis showed large and medium molecular proteinuria.

What is renal tubular proteinuria? 

Renal tubular proteinuria refers to renal tubular reabsorption dysfunction, affecting the re-absorption of protein in the glomerular filtrate caused by proteinuria. Common in various causes of renal tubular - interstitial diseases, such as pyelonephritis, analgesic nephropathy, antibiotic kidney damage, heavy metals (mercury, cadmium, gold, etc.) poisoning, congenital polycystic kidney disease, renal medullary cystic disease , Sponge kidney and various congenital renal tubular diseases (such as renal tubular acidosis, Fanconi syndrome) and so on. Such proteinuria general content <2g / 24h urine, mostly in 1g / 24h urine or so. Its characteristics to small molecular weight protein, such as lysozyme, β2 microglobulin and so on, albumin less. Urinary protein disc electrophoresis showed small molecule proteinuria.

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