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What are the pathogenic factors of nephrotic syndrome?

What are the pathogenic factors of nephrotic syndrome?

What are the pathogenic factors of nephrotic syndrome? Nephrotic syndrome is a kind of disease which is very harmful to the patients. What are the pathogenic factors of nephrotic syndrome? The specific content of experts from Qingdao Jing K...


What are the pathogenic factors of nephrotic syndrome? Nephrotic syndrome is a kind of disease which is very harmful to the patients. What are the pathogenic factors of nephrotic syndrome? The specific content of experts from Qingdao Jing Kang kidney disease hospital to explain.

What are the pathogenic factors of nephrotic syndrome?

1. edema: hypoalbuminemia causes a decrease in plasma colloid osmotic pressure, and water enters the interstitial space from the lumen, which is the major cause of edema.

2. hyperlipidemia: high cholesterol and / or hypertriglyceridemia, serum concentrations of LDL, VLDL, and lipoprotein (a) increase, often coexisting with hypoalbuminemia. Its mechanism is related to the increase of hepatic synthesis and the decrease of lipoprotein catabolism.

3. proteinuria: molecular barrier and charge barrier when the glomerular filtration membrane in particular charge barrier damage, glomerular filtration membrane of plasma protein (to albumin based) permeability increase induced by protein content in urine increased, when more than the distal tubule reabsorption capacity, the formation of a large number of proteinuria.

4. plasma protein changes: large amounts of albumin are lost from urine and promote the compensatory synthesis of albumin in the liver. When the liver is not strong enough to overcome the loss of albumin synthesis increased, appeared hypoalbuminemia, in addition, because of poor appetite, insufficient protein intake, malabsorption or loss is hypoalbuminemia due to gastrointestinal mucosal edema.

Li Yuan (a pseudonym) appeared in 2 years ago after a cold eyelid edema, then no backache, back pain, abdominal pain, joint pain, gross hematuria, no rash, limb skin bleeding, to the local county hospital, then check the urine: urine protein (3+), diagnosed as nephrotic syndrome. "" Prednisone Acetate Tablets 40mg QD, given Po oral drug for 1 weeks: routine urine urine protein (-), then continue to increase hospital oral medication, rule by drugs, many times during the review of urine were negative, six months before the patient was admitted to the local clinic oral Chinese herbal medicine treatment, 3 months after taking the urine check again general: the urinary protein (3+), and this came to our hospital for further control of the disease, clinic with "income nephrotic syndrome" in our hospital. After 21 days of hospitalization, foam in the urine disappeared, urine protein negative, the body no symptoms. In August 28, 2014, the hospital went back to the hospital. The hormone disappeared, and the hormone safety was reduced to 1. The urine protein remained negative.

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