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What are the manifestations of polycystic kidney disease and

2017-03-01 11:32

Clinical manifestation

This disease was morphologically normal or slightly larger size of renal cysts, number and size gradually increased and increased with the increase of age, the majority of cases to 40 ~ 50 years old kidney volume growth to a considerable extent before the onset of symptoms. The main manifestations were bilateral enlargement of the kidney, renal pain, hematuria, hypertension and so on.

1 renal enlargement of bilateral renal lesions in asymmetry, size differences, to late two kidney filled the entire abdominal cavity, are distributed on the surface of many renal cyst, the kidney shaped irregular, uneven, hard texture.

Pain in 2 kidney area is one of the important symptoms, often as low back pressure or dull pain, also have pain, sometimes pain. Pain may be due to physical activity, walking time is too long, sedentary, etc., can be reduced after bed. Cause of renal hemorrhage, stone or infection is sudden or mobile.

3 of the patients with hematuria showed microscopic hematuria, but there were paroxysmal hematuria. Bleeding over a long period of blood clots through the ureter can cause colic. Hematuria is often accompanied by white blood cells and proteinuria, urine protein quantity is less, generally no more than 1.0g/d. Pyuria obviously, renal hematuria increased infection, back pain and fever.

4 high blood pressure is a common manifestation of ADPKD, before the increase in serum creatinine, about half of the high blood pressure, which is associated with the oppression of the surrounding tissues of the cyst, activation of the renin angiotensin aldosterone system. In the past 10 years, Graham PC, Torre V and Chapman AB have confirmed that the normal renal tissue, cysts adjacent to the stroma and cyst epithelial cells increased renin particles, and increased renin secretion. These are closely related to the growth of cysts and the occurrence of hypertension. In other words, the rapid development of high blood pressure cysts, can directly affect the prognosis.

Not all 5 renal disease happen sooner or later renal insufficiency, inpidual cases in adolescence is kidney failure, usually before the age of 40 there is little decline in renal function at the age of 70, about half remain renal function, but the process of hypertension to renal failure is greatly shortened, there are also inpidual patients 80 years of age can still maintain kidney function.

6 of patients with polycystic liver disease found in the middle age of ADPKD, about half of them have polycystic liver, about 70% after the age of about 60. It is generally thought that the development is slower and more than 10 years later. The cyst is lost by bile duct expansion member. In addition, pancreatic and ovarian cyst can also occur, with a higher rate of colonic perticulum.

Adult polycystic kidney symptoms in early adulthood, often with hypertension or renal insufficiency, hematuria, abdominal palpation can find large polycystic kidney. The renal function was slowly decrease, hypertension, obstruction or pyelonephritis, is an important cause of accelerated renal damage. Autosomal recessive (infantile) polycystic kidney disease in infancy, the clinical rare, mostly in infancy, a small number of mild patients can live to adulthood.

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