Objective:Investigate the incidence of complications of nephrotic syndrome and its influencing factors. Methods a total of 40 patients with nephrotic syndrome were selected to analyze the causes of complications in these patients. The infec...
Objective:Investigate the incidence of complications of nephrotic syndrome and its influencing factors.
Methods a total of 40 patients with nephrotic syndrome were selected to analyze the causes of complications in these patients. The infection rate was 27.50%, thrombosis 5%, acute renal insufficiency probability is 10%, the disorder of lipid metabolism rate was 67.50%, the incidence rate of nephrotic syndrome complicated with lipid metabolic disorder patients was significantly higher than that of other complications (P<0.05).
Conclusion the incidence of complications in patients with nephrotic syndrome and the influencing factors were analyzed, and the corresponding treatment measures were found, which was helpful to reduce the complication rate.
Nephrotic syndrome refers to combination syndrome with glomerular lesions. Nephrotic syndrome needs a long time treatment, there are some patients due to nonadherence and disease found late resulting in the deterioration of the situation. Therefore, the implementation of early treatment for patients with nephrotic syndrome can avoid the deterioration condition of patients with increased difficulty of treatment. Nephrotic syndrome patients are prone to complications, thus affecting the treatment, therefore, to take effective measures for the prevention of complications of nephrotic syndrome is of great significance. In this paper, the incidence of complications in patients with nephrotic syndrome and the influencing factors were analyzed, so as to provide evidence for the prevention and treatment of complications in patients with nephrotic syndrome:
1.1 basic information
Selected patients with nephrotic syndrome in 40 cases, the time for the March 2014 - March 2016, the patients were diagnosed with nephrotic syndrome, male to female ratio was 36/4, aged 43 -71 years old, average age is (56.69 + 6.52) years old, the average duration of (11.23 + 2.36) years; among them, primary 22 cases of patients with nephrotic syndrome, 18 cases of secondary nephrotic syndrome patients.
Collect the clinical data of 40 cases of patients with nephrotic syndrome, the clinical data of the patients were analyzed, including the complication incidence, types and clinical examination of the patients and the clinical manifestations, medical history, blood pressure, body mass index.
1.3 observation index
The types and incidence of complications in patients with nephrotic syndrome, the clinical examination results and clinical manifestations, past medical history, blood pressure and body mass index were observed and analyzed.
1.4 data processing
The full text of the research data are strictly input SPSS22.00 software for statistical processing, count data using chi square test, measurement data using t test. P<0.05, statistically significant.
2.1 The incidence of complications of nephrotic syndrome
The main incidence of complications in patients with nephrotic syndrome were: the infection probability is 27.50% (11 cases), thrombosis rate was 5% (2 cases), acute renal failure probability is 10% (4 cases), lipid metabolic disorder rate was 67.50% (27 cases). The odds of lipid metabolism disorder in patients with nephrotic syndrome were significantly higher than those of other complications, and the difference was significant (P<0.05).
2.2 Influencing factors of complications of nephrotic syndrome
Infection. In patients with nephrotic syndrome under the role of hormones, there will be immunity decline, resulting in patients prone to infection, in patients with post infection, the efficacy of corticosteroids may be affected, death can occur in severe case; at the same time, the long-term use of immunosuppressive agents, may lead to patients with thymus atrophy, which will reduce the level of thymic hormone secretion, increase the risk of infection in patients related.
Disorder of lipid metabolism: the increase of lipoprotein and lipid production in patients with nephrotic syndrome can lead to the disorder of lipid metabolism.
Thrombosis: Patients with nephrotic syndrome in the presence of low protein, high blood lipid, the patient can appear blood concentration, after the formation of thrombosis, resulting in patients with coronary atherosclerosis. Mesangial cell proliferation is also affected by lipid, resulting in damage to the renal tubules, thereby promoting the development of glomerular sclerosis.
Acute renal insufficiency: in patients with nephrotic syndrome were the main cause of renal dysfunction as osmotic nephrosis and nephritis, glomerulonephritis (aggressive), distal renal tubular plug (protein tube), bilateral renal vein thrombosis, acute interstitial nephritis (drug induced), renal interstitial edema, hemodynamic changes etc..
The treatment of nephrotic syndrome is more difficult, and prone to recurrence of the situation, thus increasing the time of treatment and treatment costs, increasing the burden on the patient's physical and economic burden. At the same time, the patients with nephrotic syndrome are prone to complications and treatment, therefore, should strengthen the analysis of factors of syndrome in patients with complications and the comprehensive influence of nephropathy, and find out the corresponding countermeasures to prevention and treatment of complications of nephrotic syndrome.
Prevention of infection: ensure the patients with nephrotic syndrome in a clean and tidy environment treatment, reasonable adjustment of the temperature and humidity treatment, and regularly used ultraviolet light disinfection for patient ward, help patients to change positions, so as to avoid cross infection. At the same time to strengthen the nephrotic syndrome patients urine volume, white blood cell changes observation, the timely patient's blood routine and liver function test , and make the corresponding record, once appear abnormal, then give patients effective treatment.
Prevention and treatment of thrombosis: Patients with nephrotic syndrome should try to drink warm water, keep the ward warm and humid, while giving nephrotic syndrome patients Pan Shengding, heparin, urokinase and other treatment to prevent thrombosis.
Disorders of lipid metabolism: recommend patients with nephrotic syndrome the diet rich in vitamins, calories and digestible food, reduce high-fat, irritating food intake. If the patient is accompanied by severe edema, the patient should ensure that the daily drinking water volume 500 ml or more, and to strengthen the control of blood pressure in patients with nephrotic syndrome .
In summary, nephrotic syndrome complicated with lipid metabolic disorders with a higher risk of clinical syndrome, should strengthen the prevention and treatment of complications, so as to reduce the complications of patients with nephrotic syndrome, promote the curative effect.
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