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Why nephrotic syndrome produces proteinuria

2017-08-22 15:40

Blood in the water and its solute through the glomerular filtration into the renal capsule to form the original urine, must pass through the capillary wall of the endothelial cells, basement membrane and epithelial cells, the three-layer structure called glomerular filtration membrane.

The three-layer membrane has a certain pore, allowing only a certain molecular weight and molecular diameter of the material through, thus forming the membrane membrane pore barrier, and three-layer structure of the surface were covered with sialyl protein, glomerular basement membrane , The outer loose layer rich in heparin sulfate, these substances in the human body fluid environment with a negative charge, the exclusion of the negatively charged solute through, thus forming the filter membrane charge barrier.

In addition, the glomerular capillaries located between the glomerular mesangial membrane of the glomerular filtration barrier regulation, and thus the glomerular filtration also play a certain impact.

Under normal circumstances, the vast majority of the blood. Proteins can not pass through the glomerular filtration barrier, especially macromolecules and negatively charged albumin is almost impossible to pass, a small amount of small molecules through the membrane protein can be reabsorbed in the renal tubular.

Thus, although about 10 to 15 kg of plasma protein flows through the kidney every day. But the protein discharged from the urine less than 150mg. In the nephrotic syndrome, due to a variety of pathological factors, the barrier effect of the membrane is destroyed, such as pore size or negative charge reduction, resulting in a large number of protein leakage, and far more than the renal tubular reabsorption capacity, So there is a lot of proteinuria.

Why nephrotic syndrome produces proteinuria

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