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Complications of nephrotic syndrome: infection

2017-07-26 16:28
Infections were before glucocorticoid and antibiotic use, is one of the leading causes of death in patients with nephrotic syndrome. Studies have shown that about 60% of children with nephrotic syndrome have one or more secondary infections. So patients with nephrotic syndrome must prevent the occurrence of infection.
Nephrotic syndrome patients prone to infection are the main factors: 1.Long term use of immunosuppressive agents, weaken the body defense capabilities. 2, urinary immunoglobulin (especially IgG) a large number of loss, catabolism accelerated and lymphocyte synthesis of immunoglobulin decreased. 3, bypass activation of complement B factor decreased, so that the immune effect of bacteria weakened, B factor decreased the degree of plasma albumin and the degree of decline consistent. 4, white blood cell function is inhibited. In addition,patients with nephrotic syndrome may have some cell inhibitory factors, so that T lymphocyte dysfunction. 5, low transferrin and low zinc deficiency. 6, serous effusion, a high degree of skin edema can weaken the local defense function caused by infection.
Bacterial infection is one of the major causes of death in patients with nephrotic syndrome. Serious infections occur mainly in children and the elderly, and there are many adults. Common clinical infections are: primary peritonitis, cellulitis, respiratory infections and urinary tract infections. Once found infection, it should be immediately treated, so as not to delay the disease, leading to exacerbations, and even death.
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nephrotic syndrome,infection,complication

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