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Share the basic knowledge of nephrotic syndrome

2017-05-18 18:01

Everyone in daily life often hear some people suffering from a variety of kidney disease, including a disease called nephrotic syndrome, which is a common clinical disease, the following is to introduce the clinical manifestations of nephrotic syndrome and treatment Care.

Clinical manifestations of nephrotic syndrome

(1) hyperlipidemia: plasma cholesterol, triglycerides, low density and very low density lipoprotein, etc. can be significantly increased.

(2) a large number of proteinuria: adult daily urinary protein more than 3.5g, nephrotic syndrome necessary for the first feature. Urine protein is mainly composed of albumin.

(3) hypoalbuminemia: plasma albumin less than 30g / L, nephrotic syndrome necessary for the second feature, mainly by a large number of albumin caused by urinary excretion.

(4) edema: is the most prominent signs. Nephrotic syndrome, varying degrees of edema, the most obvious to the loose tissue. Usually there will be a high degree of edema.

(5) Complications: infection {common}, thrombosis, embolism, acute renal failure, other (atherosclerosis, coronary heart disease, protein malnutrition, child growth retardation)

Treatment of nephrotic syndrome

(1) traditional Chinese medicine treatment: such as Tripterygium, etc., can be combined with hormones and cytotoxic drugs.

(2) general treatment: bed rest to edema subsided, but should still maintain a moderate bed and bedside activities, given high calorie, low fat, high vitamin, low salt and rich in soluble fiber diet, kidney function Give a normal amount of high quality protein.

(3) inhibition of immune and inflammatory response (the main treatment) A adrenal glucocorticoid: the use of principles for the initial enough, slow drug reduction and long-term maintenance. Commonly used drugs for prednisone. B cytotoxic drugs: such as cyclophosphamide, longer than the combination of hormones. C cyclosporine: can play a role in the selective inhibition of T helper cells and T cytotoxic effector cells.

(4) complications prevention and treatment A: infection: select sensitive, potent and no renal toxicity of antibiotics for treatment B: thrombosis, embolism: blood hypercoagulable state to give anticoagulants such as heparin, supplemented by platelet depolymerization, embolism Timely given urokinase or streptokinase thrombolysis, and with the application of anticoagulants. C: acute renal failure: diuretic ineffective and dialysis indications to reach the dialysis treatment

(5) symptomatic treatment: a: diuretic edema: the majority of patients after the use of adrenal glucocorticoid and limited water, sodium can be achieved after diuretic swelling purposes. The above treatment can not be used to reduce edema diuretics include thiazide diuretics, potassium diuretics, furosemide, osmotic diuretics, intravenous infusion of plasma or plasma albumin. B reduce urinary protein: the use of angiotensin converting enzyme inhibitors and other antihypertensive drugs. C: lipid-lowering therapy: lipid-lowering drugs such as lovastatin.

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