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Symptomatic characteristics of nephrotic syndrome

2017-05-18 17:45

Symptomatic characteristics of nephrotic syndrome.Nephrotic syndrome (NS) is not an independent disease, but a group of clinical symptoms in glomerular disease. Typical levels of proteinuria (daily> 3.5g / 1.73m2 body surface area), hypoalbuminemia (plasma albumin <30g / L), edema with or without hyperlipidemia diagnostic criteria should be a large number of protein Urine and hypoproteinemia. Nephrotic syndrome specific symptoms of the following characteristics:

1, a large number of proteinuria: a large number of proteinuria is a sign of nephrotic syndrome, the main component is albumin, also contains other plasma protein composition, glomerular basement membrane permeability is the basic cause of proteinuria, charge barrier and mechanical Barrier (glomerular capillary pore size barrier) changes, renal tubular epithelial cell reabsorption and catabolism on the formation of proteinuria also have an impact.

2, hypoproteinemia: nephrotic syndrome is necessary for the second feature, serum albumin less than 30g / L, nephrotic syndrome, liver synthesis of albumin increased, when the diet to give enough protein and hot card, Patients with liver synthesis of albumin about 22.6g per day, significantly increased than normal 15.6g per day, when the liver synthesis of albumin compensatory effect is not enough to make up for the loss of urinary protein, the emergence of hypoproteinemia.

3, edema: nephrotic syndrome patients with the most noticeable symptoms is gradually increased systemic edema, the initial morning eyelids, facial, ankle edema. With the development of edema spread to the body, and the emergence of pleural effusion, ascites, pericardial effusion, mediastinal fluid, scrotum or labia edema, pulmonary edema can also occur, severe eyes can not open, head and neck thicker, skin Wax-like pale, plus the chest, the presence of ascites, it appears obvious difficulty breathing, can not be supine can only sit, if the skin damage, the tissue fluid overflow and difficult to stop, edema and postural relationship is obvious.

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