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Therapeutic Principle of Hypertensive Nephropathy

2017-05-31 10:46

Hypertension can directly cause kidney damage, the so-called hypertensive nephropathy, including benign renal arteriosclerosis and malignant renal arteriosclerosis. Benign renal arteriosclerosis is a long-term high blood pressure lead to renal arteriovenous hyaline, causing kidney ischemia, hypoxia, fibrosis, sclerosis, necrosis, and then renal insufficiency, and ultimately will develop to uremia.

The treatment of hypertension nephropathy

1. Vascularization

Expansion of the kidneys at all levels of small arteries, because high blood pressure stimulation led to glomerular microvascular ischemia and hypoxia. The purpose of vasodilator is to improve the blood supply to the blood circulation of the kidney system, to alleviate the renal ischemia and hypoxia of the existing cells, to prevent the damage of renal vascular endothelial cells and promote systemic blood circulation.

2. anti-inflammatory

Reduce the infiltration of inflammatory cells, to avoid inflammation of endothelial cells damage. Fundamentally solve the renal fibrosis of the initiating factors inflammatory response, blocking the process of renal fibrosis, protect the kidney inherent cells.

3. anticoagulation

Reduce the formation of microvessels in glomerular capillaries, lay the foundation for the repair of endothelial cells. Expansion of the kidney at all levels of arteries and peripheral blood vessels, effectively improve the hypercoagulable state.

4. Degradation

Glomerular capillaries in the inflammatory cells will increase the extracellular matrix extracellular secretion, only the proliferation of extracellular matrix to the degradation of excreted, can play a role in repair.

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