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End stage renal failure using CCB can reduce mortality

2016-12-31 10:00

In the center of a higher incidence of dialysis patients with vascular disease, and calcium channel blockers (CCBs) is widely used for the treatment of end-stage renal disease (ESRD) in patients with hypertension, but the long-term prognosis is related to the application of these drugs is not clear.
To determine the association between CCB use and mortality in patients with ESRD, Kestenbaum and colleagues from the Department of Biostatistics, University of Washington, and B, a school of public health and community medicine, conducted a cohort study.
They used data from the American kidney data system to study the incidence and mortality of dialysis, 4065 patients with ESRD were randomly selected. All of these patients began dialysis in 1996. This research has made liver harm cough has 60 days to collect clinical data (including medication), and then determine the survival and causes of death. Cox proportional hazards model was used to estimate the relative risk of death associated with CCB use (RR).
A total of 3716 patients (91). 4%) information available for analysis. 51% of the patients were treated with a CCB. Application of CCB reduced total mortality by 21% (RR). 79, confidence interval: 0. 69 ~ 0. 90) cardiovascular specific mortality was reduced by 26% (RR = 0). 74, confidence interval: 0. 60 ~ 0. 91). For patients with cardiovascular disease, the use of CCB can reduce total mortality by 23% (RR). 77, confidence interval: 0. 65 ~ 0. 0) cardiovascular mortality was reduced by 32% (RR = 91). 68, confidence interval: 0. 53 ~ 0. 87).
Chronic renal failure
The two kidneys of a total of only 250 grams of weight, once the damage to the kidney tissue, it can not repair or regeneration, too much damage, it will occur irreversible renal failure, the risk of life.
An internationally renowned kidney disease expert once said: "the kidney is life." This sentence is not alarmist, but as sure as a gun cautionary words. The two kidneys of a total of only 250 grams of weight, once the damage to the kidney tissue, it can not repair or regeneration, too much damage, it will occur irreversible renal failure, the risk of life.
Therefore, we must protect the kidneys. Do not use direct damage to the kidney: drugs such as aminoglycoside antibiotics, amphotericin B, tetracycline, iodine radiography medicine, mercury agent, phenylbutazone, phenacetin and paracetamol; allergic reactions caused kidney damage drugs rifampicin and phenytoin.
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