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Is the reduction of urine volume early signs of renal failur

2018-02-01 16:01

Many patients with renal failure clinically say they have had symptoms of oliguria, so is oliguria an early sign of renal failure? What should we pay attention to? The symptoms of oliguria or anuria in patients with nephropathy are probably due to acute renal failure.

Is the reduction of urine volume early signs of renal failure?

The normal person takes in the water liquid and the discharge liquid every day is equal, about 2500ml, among them daily urine volume average 1500 ml. if the nephropathy patient's daily urine quantity is less than 400 ml, is "oliguria". Less than 100 ml is “anuria”.

Metabolic wastes such as creatinine, urea nitrogen and creatine are mainly excreted from urine. Generally speaking, each person produces 35 g of metabolic nitrogen waste daily. 15ml urine dilution is required for each gram of waste. Therefore, the minimum effective daily urine volume should be 500ml. The higher the protein content, the more urine is required to exclude metabolic waste. When oliguria is anuria. The body accumulates too much waste and produces symptoms of poisoning.

Chronic renal failure, the kidney itself has been seriously damaged, in the use of drugs should be reasonable, if the drug can not be discharged smoothly from the urine, but also may have toxic symptoms, so patients with renal failure should be careful. The doctor should adjust the drug used in clinic according to the patient's condition. 70% were completely or partially excreted through the kidney. Therefore, changes in renal function would inevitably lead to changes in pharmacokinetics and pharmacokinetics. It is important for patients with renal failure to regulate the dosage of drugs correctly.

The dosage of drugs in chronic renal failure should be reduced according to the slow down of the drug, but the effective concentration in blood should be maintained.

To understand the characteristics of pharmacokinetics and pharmacokinetics of common drugs. To understand the renal function and other pathophysiological conditions of the patients in detail; Familiar with the medication methods of renal dysfunction, the first choice of relatively small renal toxicity drugs; If nephrotoxic drugs are indeed used, the dosage should be reduced in accordance with the corresponding methods; The dosage of some drugs, especially those excreted by kidney, should be adjusted according to the degree of renal dysfunction. Finally, the disease should be carefully observed, timely detection of adverse reactions, and appropriate treatment.

If kidney disease patient, appear suddenly oliguria or anuria symptom, is disease is serious commonly. This is a signal of acute renal failure. This condition is more commonly seen in acute effective blood insufficiency, prerenal azotemia, acute urinary tract obstruction, and retrorenal renal failure.

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