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Teach you to read IgA nephropathy test sheet

2017-06-14 17:47

Saw the laboratory results on a lot of patients with IgA nephropathy, are not aware of their condition to a what extent, if any single test shows "Lee classification I", some "Lee grade III", so what is it how to pide the grade of Lee, help patients understand this problem better to understand their condition, then take a look at the relevant content.

The following is a detailed description of the Lee classification

(a) IgA nephropathy Lee grade I: the patients most normal glomeruli, occasionally mild mesangial broadening (segments) with and (or) without cell proliferation, tubules and interstitium showed no change, this is the Lee classification of the lightest type.

(two) IgA nephropathy, Lee grade II: this stage of the patient shows focal mesangial proliferation and sclerosis (< ten. Fifty). There are rare small crescentic, renal tubules and renal interstitium without damage. This phase of the lesion is more severe than the first stage, with focal lesions under light microscopy, affecting a small number of glomeruli (FOCI) and partial lobules (segments) of the glomerulus.

(three) Lee grade III: IgA nephropathy patients showed diffuse glomerular mesangial proliferation and broadening (occasionally focal segmental), I see the new month; renal tubular and interstitial changes are out of the focal renal interstitial edema, occasionally rare cell infiltration, tubular atrophy. Cell infiltration can lead to an inflammatory response, which, if not stopped in time, can lead to phenotypic changes in renal function cells and release a series of nephrotoxic factors during the course of inflammation. The area of glomerulosclerosis will increase, the renal tubular atrophy will also increase, and there will be renal interstitial renal vascular fibrosis.

(four) IgA nephropathy grade Lee grade IV: glomerular lesions are severe diffuse mesangial proliferation and sclerosis, and partial or all glomerular sclerosis, visible crescent (<45%). Atrophy of renal tubules, infiltration of renal interstitium, interstitial cells of kidney. This type of crescent take as an example: the new moon in this type of body is close to 50&#xFF05, can be said; if the patients do not pay attention to it, is likely to reach this figure, but research shows that when more than 50&#xFF05 of the total number of glomerular crescents; above, namely crescentic glomerulonephritis (or crescentic IgA nephropathy) in addition, it is the type II lupus nephritis outside the most common immune complexes of crescentic glomerulonephritis, its severity is self-evident.

(five) IgA nephropathy Lee grade V: the nature of glomerular lesions is similar to grade IV, but more severe; glomerular crescent forming >45% renal tubules and renal interstitial lesions are similar to grade IV, but are more severe. During this period, IgA nephropathy is the most severe lesions in IgA nephropathy, so the treatment is also the most difficult, IgA nephropathy treatment and IV therapy, just need more stringent treatment options, perhaps in the treatment time will be relatively longer.

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