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Pathogenic factors of Henoch Schonlein purpura nephritis!

2017-02-13 16:53

Henoch Schonlein purpura nephritis often occurs in children under 10 years of age, adults (>20 years old) is rare. Often in the cold season. Approximately 1/3 of patients had a history of bacterial, viral, and other infections, but does not demonstrate a positive relationship with streptococcal infection. About 1/4 of patients with fish, shrimp allergy or vaccination, drug related.

The majority of patients were benign, self limiting process, the majority of patients were cured within a few weeks after proper treatment. But there are recurrent or persistent for several months and years, about 50% of patients with recurrent disease.

About allergic purpura nephritis in the incidence of allergic purpura, the report is different, the relevant Professor statistics reported 2840 cases at home and abroad, there are purpura nephritis accounted for 37. 6%.

Henoch Schonlein purpura nephritis is a secondary lesion of allergic purpura, and the cause of allergic purpura is not clear, may be related to infection and allergic reactions. Some cases had infection before the onset of the disease, the most common is the upper respiratory tract infection (non-specific or streptococcal infection), such as chlamydia, chickenpox and parasites, etc.. Many cases of disease before drugs (antibiotics, iodine amine, isoniazid, salicylate, barbital and iodide) or food (milk, fish, shrimp, crab and clam) allergy. It is considered to be an immune complex disease. IgA plays an important role in pathogenesis. Acute phase serum IgA significantly increased, IgA affinity can produce high molecular weight polymer, more than 90% cases of glomerular and skin vascular walls of IgA positive. Patients with acute phase serum factor XIII activity and low glomerular fibrin (ogen) exist, indicating that the coagulation mechanisms involved in the pathogenesis of the disease.

Through the introduction of the above symptoms of kidney disease, I believe that we have a certain understanding, in addition to the small series to remind you that the body is unwell, please seek medical treatment as soon as possible, do not delay the disease.

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