Low creatinine causes and hazards
Human creatinine substances are mainly muscle metabolism of creatine production, creatinine excreted through the kidneys in vitro. Under normal circumstances, because the bodys muscle volume is relatively stable, so the formation of creatin...
Human creatinine substances are mainly muscle metabolism of creatine production, creatinine excreted through the kidneys in vitro. Under normal circumstances, because the body's muscle volume is relatively stable, so the formation of creatinine
The amount is also constant, the level of serum creatinine depends mainly on the number of renal excretion of creatinine. Kidney compensatory function is very strong, if the two kidneys are normal, then as long as one
Kidney function, serum creatinine can be maintained at normal levels. In other words, the degree of renal damage accounted for more than half of the entire kidney, it will cause low serum creatinine live low. Therefore, serum creatinine does not reflect early, mild renal dysfunction.
Low creatinine may be associated with anemia, muscular dystrophy, muscle atrophy, leukemia, diabetes insipidus and other diseases. Such as creatinine measured value is slightly lower than the normal creatinine, can be re-check once.
Such as urea nitrogen and creatinine value increased, and urea nitrogen / creatinine ratio is low, which is the cause of low creatinine is prompted the possibility of renal parenchymal damage.
When the high serum creatinine that the patient's renal function problems, the ability of the kidneys to reduce metabolic waste, the body of some harmful toxins can not be normal excreted, first damaged kidney cells in the form of phenotypic transformation, the formation of pathological changes, Internal fibroblasts are transformed into myofibroblasts.
At the same time violated and stimulated the inherent normal renal tissue, the occurrence of the same lesions, resulting in the kidney from point to surface, from the local to the whole, to expand the excitement of the spread process, which entered the equipment damage period, Continue to cause damage, the discharge of waste function has been reduced, resulting in creatinine and other toxins gathered in the body, resulting in blood creatinine, elevated urea nitrogen, urinary creatinine decreased, renal filtration rate decreased. At the same time patients will have high blood pressure, high swelling and other symptoms of the body.
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