What is creatinine and what does it do?
Serum creatinine, is generally considered to be endogenous creatinine, endogenous creatinine is the product of human muscle metabolism. In the muscle, creatine mainly through the irreversible non-enzyme dehydration reaction slowly formed cr...
Serum creatinine, is generally considered to be endogenous creatinine, endogenous creatinine is the product of human muscle metabolism. In the muscle, creatine mainly through the irreversible non-enzyme dehydration reaction slowly formed creatinine, and then released into the blood, with the urine excretion. Therefore, serum creatinine and the body of the total amount of muscle close, not susceptible to diet. Creatinine is a small molecule material, through the glomerular filtration, rarely absorbed in the renal tubules, the daily production of creatinine, almost all with the urine, generally not affected by urine. Clinical detection of serum creatinine is commonly used to understand one of the main methods of renal function.
What is serum creatinine normal level ?
Blood creatinine normal value of the standard of each hospital is not the same, in general, serum creatinine normal standard: 44-133μmol / L, when the serum creatinine more than 133μmol / L means that the kidney injury, renal dysfunction, renal failure. (133umol / L or more for the inflammatory injury, 186μmol / L for renal dysfunction, 451μmol / L for renal failure [late (serum creatinine value of more than 707umol / L) for uremia]
Serum creatinine (SCr) normal:
Male 53 to 106 micromoles / liter (0.6 to 1.2 mg / dl);
Female 44 to 97 micromoles / liter (0.5 to 1.1 mg / dl).
Children: 24.9 ~ 69.7μmol / L.
What does a high creatinine level mean?
Serum creatinine concentration changes mainly by the glomerular filtration capacity (glomerular filtration rate) to decide. Filtration capacity decreased, the creatinine concentration increased. Serum creatinine above normal means most of the damage to the kidneys, serum creatinine can be more accurate response to renal parenchymal damage, not sensitive indicators. Because the glomerular filtration rate decreased to normal 1/3, the serum creatinine was significantly increased. Meaning that because the human kidney metabolic ability, when the kidney injury is generally less than the general feeling of discomfort is not obvious, so many people when the real nausea, vomiting, dizziness, in fact, the kidneys have been seriously injured, then the serum creatinine began to rise significantly The Glomerular filtration rate dropped to 50% before the serum creatinine can be normal, that is, functional renal unit lost more than half of the time, when this is the compensation for chronic renal failure, the general provisions of this period of serum creatinine 176.8μmol / L (2 mg / dl). Glomerular filtration rate dropped to 25% below the serum creatinine will be sharply increased, up to 5mg / dl above, this time generally uremic period. Renal function completely lost (such as acute renal failure) when the serum creatinine increased 88.4 ~ 265.2μmol / L, such as less than this range, indicating that there are residual functional nephron, otherwise explained skeletal muscle dissolution.
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