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Why does hypertension cause hypertensive nephropathy?

2017-10-16 16:54

When suffering from high blood pressure and not cured in time, it is likely to lead to hypertensive nephropathy, then why hypertension cause hypertensive nephropathy?

Why does hypertension cause hypertensive nephropathy?

Hypertension can directly cause kidney damage, which is called hypertensive nephropathy, including benign renal arteriolar sclerosis and malignant renal arteriolar sclerosis. Benign renal arteriolosclerosis is long-term hypertension leads to renal arteriolar hyalinization, causing kidney ischemia and hypoxia, fibrosis, atherosclerosis, necrosis, and renal insufficiency, eventually developed into uremia.

The degree of pathological changes is related to the duration and severity of hypertension. Glomerular lesions are fibrous and vitreous degeneration, afferent arterial glass degeneration, renal tubular atrophy, renal interstitial fibrosis, and interlobular artery and arcuate artery may also have varying degrees of intimal thickening. Malignant renal arteriolosclerosis is due to the rapid development of hypertension caused by renal artery diffuse lesions, resulting in rapid deterioration of renal function.

The histological features were the necrosis of the interlobular artery and the small artery. It can diffuse into the afferent arteriole, and the intima and smooth muscle cells of the inter - aortic artery proliferated, showing "onion skin" change. The majority of patients with hypertension can have kidney changes, with age, glomerulosclerosis is also aggravated, about 15% of hypertension will develop into uremia.


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