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Pathogenesis of renal failure!

2016-12-24 10:44
Gross renal volume, soft, pale renal cortex, ischemia, dark red medulla. Microscopically, the tubular epithelium was flattened, some showed cloudy swelling, degeneration and shedding, and there were tubes and exudates in the lumen. Poisoning caused by kidney, degeneration and necrosis of epithelial cells in proximal tubules, the basement membrane to protect its integrity; induced by renal ischemia, epithelial cell necrosis, scattered in the tubular section, the basement membrane rupture, often ulceration and renal interstitial small round cell infiltration and visible edema, a part of the patients died of acute renal tubular necrosis in kidney, no morphological changes of renal tubules under the microscope, so named tubular necrosis, is not very appropriate, but in these cases, the electron microscope, sometimes can still be seen in renal tubular epithelial cells mitochondria deformed, endoplasmic reticulum disappeared, micro cilia, some parts have a micro fissure in basement membrane. Glomerular and renal arterioles generally do not change, only disseminated disseminated intravascular coagulation, glomerular capillaries will be seen in the presence of fibrin thrombus. At fifth to 6 days of disease, necrotic tubular epithelial cells begin to develop. If the newborn is intact basement membrane epithelial cells quickly cover the membrane, the tubular morphology returned to normal. But there are basement membrane spoilers, epithelial cells can not regenerate, replaced by connective tissue defect.
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