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Why diabetes will evolve into uremia?

Why diabetes will evolve into uremia?

Diabetes and uremia, these two seemingly unrelated diseases have a very close relationship. Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus, which is characterized by persistent proteinuria. In diabeti...


Diabetes and uremia, these two seemingly unrelated diseases have a very close relationship. Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus, which is characterized by persistent proteinuria. In diabetic patients, the incidence of DN is about 34.7%, second only to cardiovascular and cerebrovascular diseases.

Why diabetes will become diabetic nephropathy further into uremia? Let us learn together with the majority of the patients in your side, there are factors that could lead to the development of the disease, so as to enhance your understanding of the disease.

(I) genetic background

It has long been recognized that the occurrence of DN has a genetic background. The incidence and severity of DN among different ethnic groups are different, and there is a certain familial aggregation in the same race. In clinic, we often find that some patients of the long-term control of blood sugar better still occur in diabetic nephropathy, and some diabetic patients blood glucose control is not satisfactory, but does not occur in diabetic nephropathy, genetic factors which have a great relationship with patients.

(two) hyperglycemia

As early as in 1985, the WHO diabetes research group confirmed that DN was present in patients with fasting glucose greater than 7.8mmol/L. Hyperglycemia is a characteristic feature of diabetes, and a series of metabolic disorders caused by hyperglycemia is an important factor in the occurrence and development of DN. Long term elevated blood glucose, renal tissue protein and glucose molecules, so that the biochemical structure of these proteins and physical and chemical crosslinking properties change, resulting in proteinuria. Intensive glycemic control can delay the occurrence of microalbuminuria in patients with type 1 and type 2 diabetes, and delay the progression of microalbuminuria to clinical proteinuria.

(three) hypertension

High blood pressure is an important factor in the occurrence and development of DN, hypertension can accelerate the development of DN and renal dysfunction, as well as uremia. For the type 1 diabetic patients, most are secondary to diabetic hypertension. The patients with type 2 diabetes, hypertension often occurs in diabetes before. In any case, high blood pressure can in turn worsen diabetes. In the stage of diabetes, the control of blood pressure is very important, especially for patients with type 1 diabetes, if the early control of blood pressure in DN can delay the development of uremia 10 - 20 years.

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