Creatinine is the product of muscle metabolism in the human body, every 20g muscle metabolism can produce 1mg creatinine. Creatinine is mainly excreted by glomerular filtration. Clinical detection of creatinine is commonly used to understan...
Creatinine is the product of muscle metabolism in the human body, every 20g muscle metabolism can produce 1mg creatinine. Creatinine is mainly excreted by glomerular filtration. Clinical detection of creatinine is commonly used to understand one of the main methods of renal function, creatinine accumulation in the body become harmful toxins, creatinine means that the patient's kidney function has been a serious injury, what is the creatinine level of uremia?
Experts say: elevated serum creatinine is often used as an important criterion for judging renal impairment. For patients with renal insufficiency, high levels of serum creatinine also assess the primary criteria for uremic disease.
what is the creatinine level of uremia?Blood serum creatinine mainly two major sources: First, exogenous serum creatinine, mainly from the intestinal to digest the protein in food; the other is endogenous serum creatinine, mainly self-organization The protein produced by the metabolism of organic acids produced by the conversion of serum creatinine. Whether it is the kind of blood creatinine are small molecules can pass to chronic glomerular filtration. Renal tubules on the absorption rarely, therefore, serum creatinine produced by the body almost all can be discharged with the urine, the urine is not affected by how much.
Normal serum blood creatinine normal value of 88 ~ 133 μmol / L. Serum creatinine content is stable in the blood, not over the values. But when the development of renal failure to the end-stage (uremic), the accumulation of serum creatinine in the body has far exceeded the capacity of the kidney. What is the creatinine level of uremia? When the serum creatinine increased to 700μmol / L, then to the stage of renal insufficiency uremia, renal failure is the most serious stage, At this time the serum creatinine metabolites and other toxic substances in the body continue to accumulate,will make the disease extremely deteriorating.
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